
Antofagasta Region Vacations & Trips from $179
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Your Antofagasta Region Vacation
Embark on your next epic adventure with an Antofagasta Region vacation package, and leave relaxed knowing all the details have been taken care of. Plus with the ability to customize your getaway, you know it'll be one to remember. With so much to do and see on a trip to Antofagasta Region, it can be tricky to know where to begin. Kick off your travels in San Pedro de Atacama at Piedra del Coyote Overlook and San Pedro Church — two popular attractions here. Another top city worthy of a spot on your itinerary is Antofagasta. Be sure not to miss Antofagasta Fish Market and Central Market. Expedia is your one-stop shop for planning your Antofagasta Region vacation. From hotels and flights, to car rentals and more, we're here to help you create a travel experience like no other.
Top destinations in Antofagasta Region

San Pedro de Atacama
The Latest Antofagasta Region Vacation Packages



Pat'ta Hoiri Hotel
Reviewed on Apr 16, 2025

Hotel Kimal
Reviewed on Jul 15, 2025
1. Plan your dream getaway to San Pedro de Atacama
San Pedro de Atacama in the Antofagasta Region of Chile offers a unique outdoor vacation experience. With its desert landscapes, adventure activities, and breathtaking natural scenery, it's a paradise for nature enthusiasts. The town is known for its charming cafes and delicious cheese, providing a delightful culinary experience. Excursions to explore volcanoes and stargazing tours are popular among visitors. Whether you're seeking thrilling outdoor adventures or simply want to immerse yourself in the stunning beauty of the desert, San Pedro de Atacama has something for everyone.
- Travelers tend to stay 3 days in San Pedro de Atacama
2. Discover Antofagasta with our vacation deals
Antofagasta, located in the Antofagasta Region of Chile, offers a diverse and captivating cultural vacation experience. With its stunning coastal views, this city is perfect for relaxation and enjoying the sunny weather. Visitors can explore the local shops and indulge in delicious seafood dishes. The city also boasts historical monuments and a bustling port, offering a glimpse into its rich history and maritime heritage. Nature enthusiasts can enjoy birdwatching along the coast, while business travelers will find a thriving commercial atmosphere. Finally, don't miss the breathtaking sunsets that paint the sky in vibrant colors each evening.
- The peak season is from January to March
- The off-peak season is from October to December
- Travelers tend to stay 3 days in Antofagasta
3. Escape to Calama with a vacation package
Calama, located in the Antofagasta Region of Chile, offers a unique atmosphere and experience for a family vacation. With its diverse geographic affinities, including deserts, ruins, and secluded areas, there is something for everyone to enjoy. Families can explore the stunning desert landscapes, visit ancient ruins, and indulge in delicious local cheese. Camping and theme park activities are also popular options for outdoor enthusiasts. For those seeking entertainment, Calama offers opera performances and a casino. Additionally, the city is home to charming churches that provide a glimpse into its rich history and culture.
- The peak season is from January to March
- The off-peak season is from April to June
- Travelers tend to stay 2 days in Calama
4. Create memories in Historical District with a vacation package
The Historical District in Antofagasta, Chile, offers a unique atmosphere for a city vacation. With its stunning coastal location, visitors can enjoy activities such as walking along the beach and exploring the historical monuments. The district also offers opportunities for theater performances, exciting excursions, and shopping. Whether you're interested in business or leisure, the area has plenty to offer. Additionally, the friendly people and diverse dining options add to the overall experience. Don't forget to visit the museums to learn more about the rich history of the region. The Historical District truly has something for everyone.
6. Book your ideal Mejillones with a vacation package
Mejillones, located in the Antofagasta Region of Chile, offers a vibrant atmosphere for beach vacations. With its stunning natural parks and beautiful beaches, it is a paradise for nature lovers. The town also boasts interesting museums that provide insights into the local culture and history. Visitors can engage in a variety of activities, including destination tours and sightseeing. Whether you want to relax on the beach or explore the surrounding natural beauty, Mejillones has something for everyone. Don't miss the opportunity to immerse yourself in the local atmosphere and enjoy a memorable vacation in this charming coastal town.
- The peak season is from January to March
- The off-peak season is from April to June
- Travelers tend to stay 4 days in Mejillones
5. Explore Toconao with a vacation package
Toconao, located in the Antofagasta Region of Chile, offers a captivating atmosphere for outdoor enthusiasts. With its stunning natural parks and picturesque landscapes, it is the perfect destination for a nature-focused vacation. Immerse yourself in the beauty of the region as you explore its geographic affinities. Whether you choose to hike through rugged canyons, visit the nearby San Pedro de Atacama for stargazing, or simply indulge in the tranquility of the area, Toconao guarantees an unforgettable experience for those seeking an outdoor adventure in the heart of Chile.
- The peak season is from July to September
- The off-peak season is from October to December
Find the Best Antofagasta Region Vacation Packages
Antofagasta Region Hotel Deals

Terrado Suites Antofagasta
Reviewed on Jun 20, 2025

Diego de Almagro San Pedro de Atacama
Reviewed on May 18, 2025

Hotel Cumbres San Pedro de Atacama
Reviewed on Aug 5, 2025
Frequently asked questions
Discover the most popular places to visit in Antofagasta Region

Plaza de San Pedro de Atacama
You can find out about the history of San Pedro de Atacama when you stop by Plaza de San Pedro de Atacama. You can seek out the local tours in this quaint area.

Valley of the Moon
Treat your eyes to the variety of colors in a deserted valley that looks like a scene from a science fiction movie.

San Pedro Church
Find out about the history of San Pedro de Atacama when you take a trip to San Pedro Church. You can seek out the local tours in this quaint area.
What to do in Antofagasta Region

San Pedro de Atacama: 3-Day Activity Combo with 4 Tours
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