Antofagasta Region Vacations & Trips from $179

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Your Antofagasta Region Vacation

Embark on your next epic adventure with an Antofagasta Region vacation package, and leave relaxed knowing all the details have been taken care of. Plus with the ability to customize your getaway, you know it'll be one to remember. With so much to do and see on a trip to Antofagasta Region, it can be tricky to know where to begin. Kick off your travels in San Pedro de Atacama at Piedra del Coyote Overlook and San Pedro Church — two popular attractions here. Another top city worthy of a spot on your itinerary is Antofagasta. Be sure not to miss Antofagasta Fish Market and Central Market. Expedia is your one-stop shop for planning your Antofagasta Region vacation. From hotels and flights, to car rentals and more, we're here to help you create a travel experience like no other.

Top destinations in Antofagasta Region

The Latest Antofagasta Region Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Modular Express Calama
Hotel Agua del Desierto
Pat'ta Hoiri Hotel
Hotel Kimal
Hotel Poblado Kimal

Best Places to Vacation in Antofagasta Region

1. Plan your dream getaway to San Pedro de Atacama

San Pedro de Atacama in the Antofagasta Region of Chile offers a unique outdoor vacation experience. With its desert landscapes, adventure activities, and breathtaking natural scenery, it's a paradise for nature enthusiasts. The town is known for its charming cafes and delicious cheese, providing a delightful culinary experience. Excursions to explore volcanoes and stargazing tours are popular among visitors. Whether you're seeking thrilling outdoor adventures or simply want to immerse yourself in the stunning beauty of the desert, San Pedro de Atacama has something for everyone.

  • Travelers tend to stay 3 days in San Pedro de Atacama

2. Discover Antofagasta with our vacation deals

Antofagasta, located in the Antofagasta Region of Chile, offers a diverse and captivating cultural vacation experience. With its stunning coastal views, this city is perfect for relaxation and enjoying the sunny weather. Visitors can explore the local shops and indulge in delicious seafood dishes. The city also boasts historical monuments and a bustling port, offering a glimpse into its rich history and maritime heritage. Nature enthusiasts can enjoy birdwatching along the coast, while business travelers will find a thriving commercial atmosphere. Finally, don't miss the breathtaking sunsets that paint the sky in vibrant colors each evening.

  • The peak season is from January to March
  • The off-peak season is from October to December
  • Travelers tend to stay 3 days in Antofagasta

3. Escape to Calama with a vacation package

Calama, located in the Antofagasta Region of Chile, offers a unique atmosphere and experience for a family vacation. With its diverse geographic affinities, including deserts, ruins, and secluded areas, there is something for everyone to enjoy. Families can explore the stunning desert landscapes, visit ancient ruins, and indulge in delicious local cheese. Camping and theme park activities are also popular options for outdoor enthusiasts. For those seeking entertainment, Calama offers opera performances and a casino. Additionally, the city is home to charming churches that provide a glimpse into its rich history and culture.

  • The peak season is from January to March
  • The off-peak season is from April to June
  • Travelers tend to stay 2 days in Calama

4. Create memories in Historical District with a vacation package

The Historical District in Antofagasta, Chile, offers a unique atmosphere for a city vacation. With its stunning coastal location, visitors can enjoy activities such as walking along the beach and exploring the historical monuments. The district also offers opportunities for theater performances, exciting excursions, and shopping. Whether you're interested in business or leisure, the area has plenty to offer. Additionally, the friendly people and diverse dining options add to the overall experience. Don't forget to visit the museums to learn more about the rich history of the region. The Historical District truly has something for everyone.

6. Book your ideal Mejillones with a vacation package

Mejillones, located in the Antofagasta Region of Chile, offers a vibrant atmosphere for beach vacations. With its stunning natural parks and beautiful beaches, it is a paradise for nature lovers. The town also boasts interesting museums that provide insights into the local culture and history. Visitors can engage in a variety of activities, including destination tours and sightseeing. Whether you want to relax on the beach or explore the surrounding natural beauty, Mejillones has something for everyone. Don't miss the opportunity to immerse yourself in the local atmosphere and enjoy a memorable vacation in this charming coastal town.

  • The peak season is from January to March
  • The off-peak season is from April to June
  • Travelers tend to stay 4 days in Mejillones

5. Explore Toconao with a vacation package

Toconao, located in the Antofagasta Region of Chile, offers a captivating atmosphere for outdoor enthusiasts. With its stunning natural parks and picturesque landscapes, it is the perfect destination for a nature-focused vacation. Immerse yourself in the beauty of the region as you explore its geographic affinities. Whether you choose to hike through rugged canyons, visit the nearby San Pedro de Atacama for stargazing, or simply indulge in the tranquility of the area, Toconao guarantees an unforgettable experience for those seeking an outdoor adventure in the heart of Chile.

  • The peak season is from July to September
  • The off-peak season is from October to December

Find the Best Antofagasta Region Vacation Packages

Antofagasta Region Hotel Deals

Terrado Suites Antofagasta

Terrado Suites Antofagasta

4 out of 5
Baquedano 015, Antofagasta, Antofagasta
Fully refundableReserve now, pay when you stay
8.2/10 Very Good! (289 reviews)
"It was a wonderful stay. Loved the view and the convenient location to food and shopping."

Reviewed on Jun 20, 2025

Terrado Suites Antofagasta
Diego de Almagro San Pedro de Atacama

Diego de Almagro San Pedro de Atacama

3 out of 5
Toconao 460, San Pedro de Atacama, Antofagasta
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $110 total per night from Aug 17 to Aug 18
$110 total
Aug 17 - Aug 18
8/10 Very Good! (293 reviews)
"Felt like we were at a resort. Food and facilities were great and close walk to town yet distance enough for a quiet and safe space."

Reviewed on May 18, 2025

Diego de Almagro San Pedro de Atacama
Hotel Cumbres San Pedro de Atacama

Hotel Cumbres San Pedro de Atacama

4 out of 5
Avenida Las Chilcas S/N, Lote 10 Parcela 2, San Pedro de Atacama, Antofagasta
$198 nightly
The price is $198 total per night from Aug 19 to Aug 20
$198 total
Aug 19 - Aug 20
8.8/10 Excellent! (444 reviews)
"A good property in atacama, well worth the stay!"

Reviewed on Aug 5, 2025

Hotel Cumbres San Pedro de Atacama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Antofagasta Region vacation package cost?
Tailor make your Antofagasta Region vacation package from as low as $179. Choose from any combination of rental cars, flights and hotels to create the getaway you've been dreaming of. Don't forget to add on a few activities!
How do I get a cheap travel package to Antofagasta Region?
Combine your bookings with Expedia to save big on your next adventure. With over 550 partner airlines and 1,000,000 properties throughout the world, your Antofagasta Region vacation package can be tailored exactly to suit your travel style. With all that extra money, why not throw in one or two interesting tours and experiences? It's an easy way to unlock even more discounts. Your dream getaway to Antofagasta Region is much closer than you thought!
What are the top hotels in Antofagasta Region?
Terrado Suites Antofagasta and ibis Antofagasta know how to make their guests feel welcome in Antofagasta. If you also plan to explore San Pedro de Atacama, check out Hotel La Casa de Don Tomas and Noi Casa Atacama. Both are very popular with travelers.
How far in advance should I book my Antofagasta Region vacation?
While not all airlines advertise tickets early, you can usually compare international flights on Expedia up to a year in advance. This is the time when you can score some fantastic deals. If you're booking late, you may still be in luck. Discounted prices occasionally appear only weeks before departure.
What does an Expedia Antofagasta Region travel package include?
Flights, rental cars and hotels, or any combination of them — it's up to you! Whether you're visiting Antofagasta Region with the kids or adventuring solo, there's a bundle to suit your style and budget. Once you've made your booking, why not add on one or two tours and experiences?
What should I know before booking an Antofagasta Region travel package?
Get ready to save with an Expedia travel package. Combine your airfares, rental cars and hotels and land exciting discounts. You're not restricted to hotels, though. Book with us and select from island resorts, city apartments and even treehouses and ranches!
Can I choose my airline with an Antofagasta Region Expedia vacation package?
Expedia offers access to more than 550 partner airlines globally, so you sure can! Just select your favorite carrier and create your ideal Antofagasta Region vacation.
Does Expedia offer Book Now, Pay Later Antofagasta Region vacation packages?
Travel can be costly, so you'll be relieved to know that Expedia has a solution to make things easier. Thanks to our partnership with online lender Affirm, you can now get the most out of your savings with a Book Now, Pay Later vacation package.
If I'm not able to travel, can I cancel my Antofagasta Region vacation package?
If your travel plans in Antofagasta Region have been upended, it's comforting to know that you can cancel your booking. If you made your booking within the last 24 hours, you may be eligible to receive a refund. If your booking is older than that, your hotel, airline or car rental company may impose a fee. For more details, check our Customer Service Portal.

Discover the most popular places to visit in Antofagasta Region

What to do in Antofagasta Region

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.