Antofagasta Region Vacations & Trips from $244

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Your Antofagasta Region Vacation

Embark on your next epic adventure with an Antofagasta Region vacation package, and leave relaxed knowing all the details have been taken care of. Plus with the ability to customize your getaway, you know it'll be one to remember. With so much to do and see on a trip to Antofagasta Region, it can be tricky to know where to begin. Kick off your travels in San Pedro de Atacama at Piedra del Coyote Overlook and San Pedro Church — two popular attractions here. Another top city worthy of a spot on your itinerary is Antofagasta. Be sure not to miss Antofagasta Fish Market and Central Market. Expedia is your one-stop shop for planning your Antofagasta Region vacation. From hotels and flights, to car rentals and more, we're here to help you create a travel experience like no other.

Top destinations in Antofagasta Region

A narrow dirt road lined with buildings and trees, with people walking and a stroller visible.

San Pedro de Atacama

San Pedro de Atacama
A desert beach with a mountain in the background.

Antofagasta

Antofagasta
A vast desert landscape with rugged mountains in the background.

Calama

Calama
A starry night sky over a mountainous landscape.

Sierra Gorda

Sierra Gorda
A pier extending into a calm sea with a small boat, a docked truck, and a distant cityscape.

Mejillones

Mejillones
A coastal city with mountains in the background.

Tocopilla

Tocopilla

The Latest Antofagasta Region Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Modular Express Calama

Hotel Modular Express Calama

$244
per person
Nov 3 - Nov 6
found 20 hours ago
Roundtrip flight included
Santiago (SCL) to Calama (CJC)
8/10 Very Good! (69 reviews)
I didn’t enjoyed my stay at Modular Express, the only thing I liked was the included breakfast and that is near the airport. Rooms are small and noisy, personal has no customer service attitude, prices are really high in their mini market and meals, and only accept card, no cash. When you go to the cafetería, there are other workers that go too, from mining companies I guess.

Reviewed on Jun 29, 2026

Hotel Agua del Desierto

Hotel Agua del Desierto

Save 100% on your flight
$362
per person
Nov 3 - Nov 6
found 20 hours ago
Roundtrip flight included
Santiago (SCL) to Calama (CJC)
9/10 Wonderful! (97 reviews)
The room was clean and just about the right size. The walls are very thin and so you can hear the guests in the next room. The staff was pleasant and courteous. Breakfast options were good.

Reviewed on Jul 21, 2026

Hotel Tulor

Hotel Tulor

Save 100% on your flight
$410
per person
Sep 29 - Oct 3
found 1 day ago
Roundtrip flight included
Santiago (SCL) to Calama (CJC)
9.2/10 Wonderful! (19 reviews)
Great concept, very convenient location, really interesting story around the hotel and its owner. Unfortunately only downside is the included breakfast which is not well attended. Would still stay again

Reviewed on Aug 23, 2026

Pat'ta Hoiri Hotel

Pat'ta Hoiri Hotel

Save 100% on your flight
$357
per person
Nov 3 - Nov 6
found 20 hours ago
Roundtrip flight included
Santiago (SCL) to Calama (CJC)
8.4/10 Very Good! (86 reviews)
The only reason I’m giving them 3 stars is because they don’t have a heater inside the rooms and we were freezing. Staff was very helpful but San Pedro is extremely cold to not offer this.

Reviewed on Jul 4, 2026

Geotel Calama

Geotel Calama

$247
per person
Nov 3 - Nov 6
found 18 hours ago
Roundtrip flight included
Santiago (SCL) to Calama (CJC)
8.8/10 Excellent! (235 reviews)
Reservation for 1 Double 2 bedrooms apartment. Changed for 2 singles. Heather non-working. Breakfast to.go offered but Non ready when leaving.

Reviewed on Jul 29, 2026

Best Places to Vacation in Antofagasta Region

1. Plan your dream getaway to San Pedro de Atacama

San Pedro de Atacama in the Antofagasta Region of Chile offers a unique outdoor vacation experience. With its desert landscapes, adventure activities, and breathtaking natural scenery, it's a paradise for nature enthusiasts. The town is known for its charming cafes and delicious cheese, providing a delightful culinary experience. Excursions to explore volcanoes and stargazing tours are popular among visitors. Whether you're seeking thrilling outdoor adventures or simply want to immerse yourself in the stunning beauty of the desert, San Pedro de Atacama has something for everyone.

  • Travelers tend to stay 3 days in San Pedro de Atacama

2. Discover Antofagasta with our vacation deals

Antofagasta, located in the Antofagasta Region of Chile, offers a diverse and captivating cultural vacation experience. With its stunning coastal views, this city is perfect for relaxation and enjoying the sunny weather. Visitors can explore the local shops and indulge in delicious seafood dishes. The city also boasts historical monuments and a bustling port, offering a glimpse into its rich history and maritime heritage. Nature enthusiasts can enjoy birdwatching along the coast, while business travelers will find a thriving commercial atmosphere. Finally, don't miss the breathtaking sunsets that paint the sky in vibrant colors each evening.

  • The peak season is from January to March
  • The off-peak season is from October to December
  • Travelers tend to stay 3 days in Antofagasta

3. Escape to Calama with a vacation package

Calama, located in the Antofagasta Region of Chile, offers a unique atmosphere and experience for a family vacation. With its diverse geographic affinities, including deserts, ruins, and secluded areas, there is something for everyone to enjoy. Families can explore the stunning desert landscapes, visit ancient ruins, and indulge in delicious local cheese. Camping and theme park activities are also popular options for outdoor enthusiasts. For those seeking entertainment, Calama offers opera performances and a casino. Additionally, the city is home to charming churches that provide a glimpse into its rich history and culture.

  • The peak season is from January to March
  • The off-peak season is from April to June
  • Travelers tend to stay 2 days in Calama

4. Create memories in Historical District with a vacation package

The Historical District in Antofagasta, Chile, offers a unique atmosphere for a city vacation. With its stunning coastal location, visitors can enjoy activities such as walking along the beach and exploring the historical monuments. The district also offers opportunities for theater performances, exciting excursions, and shopping. Whether you're interested in business or leisure, the area has plenty to offer. Additionally, the friendly people and diverse dining options add to the overall experience. Don't forget to visit the museums to learn more about the rich history of the region. The Historical District truly has something for everyone.

6. Book your ideal Mejillones with a vacation package

Mejillones, located in the Antofagasta Region of Chile, offers a vibrant atmosphere for beach vacations. With its stunning natural parks and beautiful beaches, it is a paradise for nature lovers. The town also boasts interesting museums that provide insights into the local culture and history. Visitors can engage in a variety of activities, including destination tours and sightseeing. Whether you want to relax on the beach or explore the surrounding natural beauty, Mejillones has something for everyone. Don't miss the opportunity to immerse yourself in the local atmosphere and enjoy a memorable vacation in this charming coastal town.

  • The peak season is from January to March
  • The off-peak season is from April to June
  • Travelers tend to stay 4 days in Mejillones

5. Explore Toconao with a vacation package

Toconao, located in the Antofagasta Region of Chile, offers a captivating atmosphere for outdoor enthusiasts. With its stunning natural parks and picturesque landscapes, it is the perfect destination for a nature-focused vacation. Immerse yourself in the beauty of the region as you explore its geographic affinities. Whether you choose to hike through rugged canyons, visit the nearby San Pedro de Atacama for stargazing, or simply indulge in the tranquility of the area, Toconao guarantees an unforgettable experience for those seeking an outdoor adventure in the heart of Chile.

  • The peak season is from July to September
  • The off-peak season is from October to December

Find the Best Antofagasta Region Vacation Packages

Antofagasta Region Essential Information

Language
Spanish
Currency
Chilean pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Cerro Moreno Intl. Airport (ANF)
Population
309,800
Top Sights
Valley of the Moon, Arco Iris Valley and Puritama Hot Springs

Antofagasta Region Hotel Deals

Diego de Almagro San Pedro de Atacama

Diego de Almagro San Pedro de Atacama

Toconao 460 San Pedro de Atacama Antofagasta
Fully refundableReserve now, pay when you stay
$113 nightly
$113 total
Aug 29 - Aug 30
8.2/10 Very Good! (401 reviews)
"Staff very helpful and friendly, although no English. Happy to converse using translation tools. Swimming pool was closed due to it being winter, which I didn’t reslise when I booked. A couple of times there was no water, no electricity and no wifi, but staff worked to resolve the issue. Breakfast ..."

Reviewed on Jul 18, 2026

Diego de Almagro San Pedro de Atacama
Hotel La Casa de Don Tomas

Hotel La Casa de Don Tomas

Calle Tocopilla Sitio 18 San Pedro de Atacama
Fully refundableReserve now, pay when you stay
$210 nightly
$210 total
Aug 29 - Aug 30
Hotel La Casa de Don Tomas
Geotel Calama

Geotel Calama

Cobija 2273 Calama Antofagasta
Fully refundableReserve now, pay when you stay
$73 nightly
$73 total
Aug 29 - Aug 30
8.8/10 Excellent! (235 reviews)
"Reservation for 1 Double 2 bedrooms apartment. Changed for 2 singles. Heather non-working. Breakfast to.go offered but Non ready when leaving."

Reviewed on Jul 29, 2026

Geotel Calama
See all 303 properties in Antofagasta Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Antofagasta Region vacation package cost?
Tailor make your Antofagasta Region vacation package from as low as $244. Choose from any combination of rental cars, flights and hotels to create the getaway you've been dreaming of. Don't forget to add on a few activities!
How do I get a cheap travel package to Antofagasta Region?
Combine your bookings with Expedia to save big on your next adventure. With over 550 partner airlines and 1,000,000 properties throughout the world, your Antofagasta Region vacation package can be tailored exactly to suit your travel style. With all that extra money, why not throw in one or two interesting tours and experiences? It's an easy way to unlock even more discounts. Your dream getaway to Antofagasta Region is much closer than you thought!
What are the top hotels in Antofagasta Region?
Terrado Suites Antofagasta and ibis Antofagasta know how to make their guests feel welcome in Antofagasta. If you also plan to explore San Pedro de Atacama, check out Hotel La Casa de Don Tomas and Noi Casa Atacama. Both are very popular with travelers.
How far in advance should I book my Antofagasta Region vacation?
While not all airlines advertise tickets early, you can usually compare international flights on Expedia up to a year in advance. This is the time when you can score some fantastic deals. If you're booking late, you may still be in luck. Discounted prices occasionally appear only weeks before departure.
What does an Expedia Antofagasta Region travel package include?
Flights, rental cars and hotels, or any combination of them — it's up to you! Whether you're visiting Antofagasta Region with the kids or adventuring solo, there's a bundle to suit your style and budget. Once you've made your booking, why not add on one or two tours and experiences?
What should I know before booking an Antofagasta Region travel package?
Get ready to save with an Expedia travel package. Combine your airfares, rental cars and hotels and land exciting discounts. You're not restricted to hotels, though. Book with us and select from island resorts, city apartments and even treehouses and ranches!
Can I choose my airline with an Antofagasta Region Expedia vacation package?
Expedia offers access to more than 550 partner airlines globally, so you sure can! Just select your favorite carrier and create your ideal Antofagasta Region vacation.
Does Expedia offer Book Now, Pay Later Antofagasta Region vacation packages?
Travel can be costly, so you'll be relieved to know that Expedia has a solution to make things easier. Thanks to our partnership with online lender Affirm, you can now get the most out of your savings with a Book Now, Pay Later vacation package.
If I'm not able to travel, can I cancel my Antofagasta Region vacation package?
If your travel plans in Antofagasta Region have been upended, it's comforting to know that you can cancel your booking. If you made your booking within the last 24 hours, you may be eligible to receive a refund. If your booking is older than that, your hotel, airline or car rental company may impose a fee. For more details, check our Customer Service Portal.

Stay near popular Antofagasta Region attractions

A desert landscape with layered rock formations and sand dunes.

Valley of the Moon

9.2/10 (244 reviews)
Treat your eyes to the variety of colors in a deserted valley that looks like a scene from a science fiction movie.
See properties
Ancient stone ruins with stepped terraces and walls in a desert landscape.
Photo by Mark Rentz

Pukara de Quitor Archaeological Site

8.4/10 (42 reviews)
You can find out about the history of Quitor with a trip to Pukara de Quitor Archaeological Site. You can seek out the local tours in this quaint area.
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Plaza de San Pedro de Atacama

8.4/10 (195 reviews)
You can find out about the history of San Pedro de Atacama when you stop by Plaza de San Pedro de Atacama. You can seek out the local tours in this quaint area.
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Tulor Archaeological Site

8.4/10 (6 reviews)
You can find out about the history of San Pedro de Atacama with a trip to Tulor Archaeological Site. You can seek out the local tours in this quaint area.
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San Pedro Church

8.6/10 (64 reviews)
San Pedro Church is just one of the places to see in San Pedro de Atacama, so why not enjoy the other things to explore during your travels? You can seek out the local tours in this quaint area.
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Cerro Paranal Observatory

8.6/10 (4 reviews)
Commune with nature and explore the great outdoors at Cerro Paranal Observatory during your travels in Antofagasta. Amble around the area's seaside or visit its shops.
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Piedra del Coyote Overlook

8.8/10 (61 reviews)
Explore the great outdoors at Piedra del Coyote Overlook, a lovely green space in San Pedro de Atacama. You can seek out the local tours in this quaint area.
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Mall Plaza Calama

8.8/10 (9 reviews)
During your trip to Calama, you can enjoy retail therapy at Mall Plaza Calama. Discover the area's desert landscape and casinos.
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What to do in Antofagasta Region

Tatio Geyser - Atacama

Small-Group Tour to Tatio Geysers Machuca Village & Rio Putana wetlands

$79
per adult
Small-Group Tour to Tatio Geysers Machuca Village & Rio Putana wetlands
Astronomical Experience with Astrophotography in Atacama

Astronomical Experience with Astrophotography in Atacama

$42
per adult
Astronomical Experience with Astrophotography in Atacama
San Pedro de Atacama: Stargazing Experience with Transfer

San Pedro de Atacama: Stargazing Experience

$33
per adult
100% of travellers recommend
San Pedro de Atacama: Stargazing Experience
See all activities in Antofagasta Region
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.