
Antofagasta Region Vacations & Trips from $244
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $2,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Antofagasta Region Vacation
Embark on your next epic adventure with an Antofagasta Region vacation package, and leave relaxed knowing all the details have been taken care of. Plus with the ability to customize your getaway, you know it'll be one to remember. With so much to do and see on a trip to Antofagasta Region, it can be tricky to know where to begin. Kick off your travels in San Pedro de Atacama at Piedra del Coyote Overlook and San Pedro Church — two popular attractions here. Another top city worthy of a spot on your itinerary is Antofagasta. Be sure not to miss Antofagasta Fish Market and Central Market. Expedia is your one-stop shop for planning your Antofagasta Region vacation. From hotels and flights, to car rentals and more, we're here to help you create a travel experience like no other.
Top destinations in Antofagasta Region

San Pedro de Atacama

Antofagasta

Calama

Sierra Gorda

Mejillones

Tocopilla
The Latest Antofagasta Region Vacation Packages

Hotel Modular Express Calama
Reviewed on Jun 29, 2026

Hotel Agua del Desierto
Reviewed on Jul 21, 2026

Hotel Tulor
Reviewed on Aug 23, 2026

Pat'ta Hoiri Hotel
Reviewed on Jul 4, 2026

Geotel Calama
Reviewed on Jul 29, 2026
1. Plan your dream getaway to San Pedro de Atacama
San Pedro de Atacama in the Antofagasta Region of Chile offers a unique outdoor vacation experience. With its desert landscapes, adventure activities, and breathtaking natural scenery, it's a paradise for nature enthusiasts. The town is known for its charming cafes and delicious cheese, providing a delightful culinary experience. Excursions to explore volcanoes and stargazing tours are popular among visitors. Whether you're seeking thrilling outdoor adventures or simply want to immerse yourself in the stunning beauty of the desert, San Pedro de Atacama has something for everyone.
- Travelers tend to stay 3 days in San Pedro de Atacama
2. Discover Antofagasta with our vacation deals
Antofagasta, located in the Antofagasta Region of Chile, offers a diverse and captivating cultural vacation experience. With its stunning coastal views, this city is perfect for relaxation and enjoying the sunny weather. Visitors can explore the local shops and indulge in delicious seafood dishes. The city also boasts historical monuments and a bustling port, offering a glimpse into its rich history and maritime heritage. Nature enthusiasts can enjoy birdwatching along the coast, while business travelers will find a thriving commercial atmosphere. Finally, don't miss the breathtaking sunsets that paint the sky in vibrant colors each evening.
- The peak season is from January to March
- The off-peak season is from October to December
- Travelers tend to stay 3 days in Antofagasta
3. Escape to Calama with a vacation package
Calama, located in the Antofagasta Region of Chile, offers a unique atmosphere and experience for a family vacation. With its diverse geographic affinities, including deserts, ruins, and secluded areas, there is something for everyone to enjoy. Families can explore the stunning desert landscapes, visit ancient ruins, and indulge in delicious local cheese. Camping and theme park activities are also popular options for outdoor enthusiasts. For those seeking entertainment, Calama offers opera performances and a casino. Additionally, the city is home to charming churches that provide a glimpse into its rich history and culture.
- The peak season is from January to March
- The off-peak season is from April to June
- Travelers tend to stay 2 days in Calama
4. Create memories in Historical District with a vacation package
The Historical District in Antofagasta, Chile, offers a unique atmosphere for a city vacation. With its stunning coastal location, visitors can enjoy activities such as walking along the beach and exploring the historical monuments. The district also offers opportunities for theater performances, exciting excursions, and shopping. Whether you're interested in business or leisure, the area has plenty to offer. Additionally, the friendly people and diverse dining options add to the overall experience. Don't forget to visit the museums to learn more about the rich history of the region. The Historical District truly has something for everyone.
6. Book your ideal Mejillones with a vacation package
Mejillones, located in the Antofagasta Region of Chile, offers a vibrant atmosphere for beach vacations. With its stunning natural parks and beautiful beaches, it is a paradise for nature lovers. The town also boasts interesting museums that provide insights into the local culture and history. Visitors can engage in a variety of activities, including destination tours and sightseeing. Whether you want to relax on the beach or explore the surrounding natural beauty, Mejillones has something for everyone. Don't miss the opportunity to immerse yourself in the local atmosphere and enjoy a memorable vacation in this charming coastal town.
- The peak season is from January to March
- The off-peak season is from April to June
- Travelers tend to stay 4 days in Mejillones
5. Explore Toconao with a vacation package
Toconao, located in the Antofagasta Region of Chile, offers a captivating atmosphere for outdoor enthusiasts. With its stunning natural parks and picturesque landscapes, it is the perfect destination for a nature-focused vacation. Immerse yourself in the beauty of the region as you explore its geographic affinities. Whether you choose to hike through rugged canyons, visit the nearby San Pedro de Atacama for stargazing, or simply indulge in the tranquility of the area, Toconao guarantees an unforgettable experience for those seeking an outdoor adventure in the heart of Chile.
- The peak season is from July to September
- The off-peak season is from October to December
Find the Best Antofagasta Region Vacation Packages
Antofagasta Region Essential Information
Language | Spanish |
|---|---|
Currency | Chilean pesos |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Closest Airport | Cerro Moreno Intl. Airport (ANF) |
Population | 309,800 |
Top Sights | Valley of the Moon, Arco Iris Valley and Puritama Hot Springs |
Antofagasta Region Hotel Deals

Diego de Almagro San Pedro de Atacama
"Staff very helpful and friendly, although no English. Happy to converse using translation tools. Swimming pool was closed due to it being winter, which I didn’t reslise when I booked. A couple of times there was no water, no electricity and no wifi, but staff worked to resolve the issue. Breakfast ..."
Reviewed on Jul 18, 2026

Hotel La Casa de Don Tomas

Geotel Calama
"Reservation for 1 Double 2 bedrooms apartment. Changed for 2 singles. Heather non-working. Breakfast to.go offered but Non ready when leaving."
Reviewed on Jul 29, 2026
Frequently asked questions
How much does an Antofagasta Region vacation package cost?
How do I get a cheap travel package to Antofagasta Region?
What are the top hotels in Antofagasta Region?
How far in advance should I book my Antofagasta Region vacation?
What does an Expedia Antofagasta Region travel package include?
What should I know before booking an Antofagasta Region travel package?
Can I choose my airline with an Antofagasta Region Expedia vacation package?
Does Expedia offer Book Now, Pay Later Antofagasta Region vacation packages?
If I'm not able to travel, can I cancel my Antofagasta Region vacation package?
Stay near popular Antofagasta Region attractions

Valley of the Moon
Pukara de Quitor Archaeological Site
Plaza de San Pedro de Atacama
Tulor Archaeological Site
San Pedro Church
Cerro Paranal Observatory
Piedra del Coyote Overlook
Mall Plaza Calama
What to do in Antofagasta Region

Small-Group Tour to Tatio Geysers Machuca Village & Rio Putana wetlands

Astronomical Experience with Astrophotography in Atacama

San Pedro de Atacama: Stargazing Experience
Other vacations you might like
- Top cities in Antofagasta Region
- Vacations and getaways similar to Antofagasta Region
- Best vacation destinations by month
- Expedia's Latest Trends
- January Vacations and Deals
- February Vacations and Deals
- March Vacations and Deals
- April Vacations and Deals
- May Vacations and Deals
- June Vacations and Deals
- July Vacations and Deals
- August Vacations and Deals
- September Vacations and Deals
- October Vacations and Deals
- November Vacations and Deals
- December Vacations and Deals
Expedia's Latest Trends
- Hotel Rooms in San Pedro de Atacama
- Honeymoon Resorts & Hotels in Magallanes y Antartica Chilena
- Hotels in Aysén del General Carlos Ibáñez del Campo Region
- Hotels with an Indoor Pool in Maule Region
- Hotels in Arica y Parinacota Region
- Hotels in O'Higgins Region
- All-inclusive Resorts in O'Higgins Region
- Beach Hotels in Los Ríos Region



















